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Key triggers or symptoms of vitamin B12 deficiency are: Tiredness Depression Hair loss Pins & needles Numbness in the hands or feet Tremors or palsies Palpitations Recurrent headaches Dizziness B12 Safety Dosing Standard treatment is to give a loading dose of intramuscular injections of 1mg per 1ml ampoule of hydroxocobalamin every other week for 4 weeks, then inject once every three to four weeks

Within this research project, the first mass spectrometric detection method for meldonium in DBS was developed and successfully validated

Its relevance is inferred from its effects on melatonin, telomere maintenance (relevant to the accelerated cellular aging seen in MS), and general immunomodulation

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